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Lorenzo's Oil is a 1992 American drama film directed by George Miller. It is based on the true story of Augusto and Michaela Odone, two parents in a relentless search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD). It was filmed primarily from September 1991 to February 1992 in Pittsburgh, Pennsylvania. ” Medicine and the Movies: Lorenzo’Oil at Century’s End Anne Hudson Jones, Ph.D., quotation beginning with “Many of the scenes ” has been taken from this article. A fourth, actually a set of storylines, are the subplots relating to the family members and friends who help the Odones. There are true aspects to many of these. 'Some people make their own miracles.' Lorenzo's Oil is a drama film, which is based on a true story. It is about a young boy who is vibrant and healthy, until he suddenly begins to have neurological problems. He starts to experience hearing loss and even to throw tantrums. His parents take him to a. True-life drama of a father and mother who battled against the odds to save their son's life. Augusto and Michaela Odone are dealt a cruel blow by fate: five-year-old Lorenzo is diagnosed with a.

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Lorenzo's Oil
Directed by	George Miller
Produced by	Doug Mitchell George Miller
Written by	George Miller Nick Enright
Starring
Music by	Various artists
Cinematography	John Seale
Edited by	Richard Francis-Bruce Marcus D'Arcy
Distributed by	Universal Pictures
December 30, 1992 (Limited) January 29, 1993 (United States) February 26, 1993 (United Kingdom)
129 minutes
Country	United States
Language	English
Budget	$30 million
Box office	$7.2 million

Lorenzo's Oil is a 1992 American drama film directed by George Miller. It is based on the true story of Augusto and Michaela Odone, two parents in a relentless search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD). It was filmed primarily from September 1991 to February 1992 in Pittsburgh, Pennsylvania.^[1] The film had a limited release in North America on December 30, 1992, with a nationwide release two weeks later on January 15, 1993. It was generally well received by the critics and received two nominations at the 65th Academy Awards but was a box office bomb, grossing only $7.2 million against its $30 million budget.

3Production
4Reception

Plot[edit]

Lorenzo is a bright and vibrant young boy living in the Comoro Islands, as his father Augusto works for the World Bank and is stationed there. However, when his parents relocate back to the United States, he begins to show signs of neurological problems (such as falling, loss of hearing, tantrums, etc.). The boy is diagnosed as having adrenoleukodystrophy (ALD), which is fatal within two years. Failing to find a doctor capable of treating their son's rare disease Augusto and his wife, Michaela, set out on a mission to find a treatment to save their son. In their quest, the Odones clash with doctors, scientists and a support group that is skeptical that anything could be done about ALD, much less by laypeople. But they persist, setting up camp in medical libraries, reviewing animal experiments, enlisting the aid of Professor Gus Nikolais, badgering researchers, questioning top doctors all over the world and even organizing an international symposium about the disease.

Despite research dead-ends, the horror of watching their son's health decline and being surrounded by skeptics (including the coordinators of the support group they attend), they persist until they finally hit upon a therapy involving adding a certain kind of oil (actually containing two specific long chain fatty acids, isolated from rapeseed oil and olive oil) to their son's diet. They contact over 100 firms around the world until they find an elderly British chemist, Don Suddaby, who is working for Croda International and is willing to take on the challenge of distilling the proper formula. The oil, erucic acid, proves successful in normalizing the accumulation of the very long chain fatty acids in the brain that had been causing their son's steady decline, thereby halting the progression of the disease. There is still a great deal of neurological damage remaining which could not be reversed unless new treatments could be found to regenerate the myelin sheath (a lipid insulator) around the nerves. The father is seen taking on the new challenge of organizing biomedical efforts to heal myelin damage in patients.

Finally, Lorenzo, at the age of 14, shows definite improvement (swallowing for himself and answering 'yes' or 'no' questions by blinking) but more medical research is still needed. Ultimately, it is revealed that Lorenzo has regained his sight, can move his head from side to side, vocalize simple sounds and is learning to use a computer.

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Cast[edit]

Nick Nolte as Augusto Odone
Susan Sarandon as Michaela Odone
Zack O'Malley Greenburg as Lorenzo Odone
Peter Ustinov as Professor Gus Nikolais
Kathleen Wilhoite as Deirdre Murphy
Gerry Bamman as Doctor Judalon
Margo Martindale as Wendy Gimble
James Rebhorn as Ellard Muscatine
Ann Hearn as Loretta Muscatine
Maduka Steady as Omouri
Mary Wakio as Comorian Teacher
Don Suddaby as himself
Colin Ward as Jake Gimble
La Tanya Richardson as Nurse Ruth
Jennifer Dundas as Nurse Nancy Jo
William Cameron as Pellerman
Peter Mackenzie as Immunosuppression Doctor
Laura Linney as Young Teacher
Elizabeth Daily as vocal effects for Lorenzo

Production[edit]

Principal photography for Lorenzo's Oil began on September 9, 1991 in Ben Avon, Pennsylvania.^[2]

Possibly to emphasize the 'Everyman' aspect of the plot (the notion that a cure could affect families and individuals anywhere), many smaller roles were played by inexperienced actors or non-actors with unusual physical features and mannerisms. For example, the poet James Merrill was noticed by a casting director at a New York public reading of his poetry. His rarefied speaking cadences were utilized in a symposium scene in which he played a questioning doctor.

Music[edit]

The film features Allegri's Miserere, Edward Elgar's cello concerto, as well as Barber's Adagio for Strings and Mozart's Ave verum corpus K.618.

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The opening song is 'Kijana Mwana Mwali' ('Song about a Young Lady'), sung by the Gonda Traditional Entertainers.

A 1960 recording of Maria Callas with the La Scala orchestra and chorus is heard singing selections from Bellini's Norma at several points.

The music for the Easter Midnight Mass scene is a Russian Orthodox Church hymn, 'Bogoroditse Devo' (Rejoice, O Virgin) from 'Three Choruses from 'Tsar Feodor Ioannovich', taken from the album Sacred Songs of Russia by Gloriae Dei Cantores.

Other music include Barber's Agnus Dei and Mahler's Symphony No. 5.

Reception[edit]

Critical response[edit]

Roger Ebert of the Chicago Sun Times gave the film four out of four stars and called it an 'immensely moving and challenging movie'.^[3] He added, 'it was impossible not to get swept up in it' and James Berardinelli of ReelViews gave it three out of four stars and claimed, 'it was about the war for knowledge and the victory of hope through perseverance.'^[4]Review aggregation website Rotten Tomatoes retrospectively collected reviews from 37 critics to give the film a score of 92%, with an average rating of 8/10, as of June 2019.^[5]

Medical response[edit]

Though the film seemed to accurately portray the events related to the boy's condition and his parents' efforts during the time period covered by the film, it was criticized for painting a picture of a miracle cure.^[6] Subsequent research with Lorenzo's oil has not clearly proven its long-term effectiveness in treating ALD after its onset.^[7] The actual subject of the film, Lorenzo Odone, died of pneumonia in May 2008 at the age of 30, having lived two decades longer than originally predicted by doctors.^[8]

Hugo Moser, on whom the character of Professor Nikolais was based, called the film's portrayal of that character 'an abomination'.^[9]

Box office[edit]

The film grossed $7,286,388 domestically with a budget of around $30 million.^[10]^[11]

Awards and honors[edit]

Lorenzo's Oil was nominated twice at the 65th Academy Awards for Best Actress in a Leading Role (Susan Sarandon) and Best Original Screenplay (George Miller & Nick Enright).

Susan Sarandon was nominated for Best Actress in a Drama at the 50th Golden Globe Awards.

The film was nominated for Best Original Screenplay Written Directly for the Screen at the WGA Awards.

Also, the film is recognized by American Film Institute in these lists:

2006: AFI's 100 Years..100 Cheers – Nominated^[12]

References[edit]